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Binding mode of the compound 47 in the CDK4 active site. The ATP binding pocket of CDK4 is shown in the form of Van der Waals surface, the compound 47 is represented in stick form (A). Hydrogen bond interaction mode of compound 47 with CDK4 (B). The ligand is anchored in the pocket by the two hydrogen bonds formed with the Val96. The two hydrogen bonds are represented by two red dashed lines.
