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. 2013 Oct 14;35(1):58–64. doi: 10.1038/aps.2013.122

Figure 2.

Figure 2

MGO-mediated activation was dependent on the Kir but not the SUR subunit of the KATP channel. (A) MGO (3 mmol/L) activated the Kir6.2/SUR2B isoform of the vascular KATP channel to a similar extent as seen in the Kir6.1 isoform. (B) A truncated form of the Kir6.2 subunit (Kir6.2Δ36) channel, capable of expressing itself without the need for the SUR subunit, opened automatically, and the channel activity was further enhanced in the presence of MGO. (C) In the presence of 1.0 mmol/L ATP and 0.5 mmol/L ADP, the basal currents of the Kir6.2Δ36 channel remained small and the application of MGO (3 mmol/L) augmented the channel activity significantly. (D) Summary of the effect of MGO on the Kir6.1/SUR2B (Kir6.1/S), Kir6.2/SUR2B (Kir6.2/S) and Kir6.2Δ36 channels (note that unlike the Kir6.2 isoform, the truncated Kir6.1 channel was not able to express by itself); bP<0.05.