TABLE 2.
Association of GERD Diagnosis With Comorbidities Present at Admission
| Variable | N (%)a | % GERDb | Bivariate Analysisc
|
Multiple Logistic Regressiond
|
||
|---|---|---|---|---|---|---|
| OR (95% CI) | P | Adjusted OR (95% CI) | P | |||
| Congenital cardiac defects | 2293 (12.3) | 15.1 | 1.67 (1.48–1.90) | .000 | 1.20 (1.04–1.38) | .010 |
| Congenital GI defects | 902 (4.9) | 19.3 | 2.20 (1.84–2.61) | .000 | 1.61 (1.33–1.95) | .000 |
| Congenital respiratory/airway | 1068 (5.8) | 25.4 | 3.30 (2.84–3.81) | .000 | 2.48 (2.11–2.90) | .000 |
| Craniofacial defects | 404 (2.2) | 23.0 | 2.70 (2.12–3.40) | .000 | 1.77 (1.35–2.30) | .000 |
| Diaphragmatic hernia | 121 (0.7) | 32.2 | 4.22 (2.85–6.15) | .000 | 2.59 (1.70–3.88) | .000 |
| Drug exposure | 930 (5.0) | 13.3 | 1.37 (1.12–1.66) | .002 | 1.43 (1.17–1.75) | .000 |
| Exposure to infections | 1381 (7.4) | 17.5 | 1.97 (1.70–2.28) | .000 | 1.67 (1.43–1.95) | .000 |
| Other genetic defects | 720 (3.9) | 15.0 | 1.57 (1.27–1.93) | .000 | 0.74 (0.58–0.94) | .014 |
| Patent ductus arteriosus | 4453 (24.0) | 16.4 | 2.17 (1.96–2.39) | .000 | 1.91 (1.72–2.13) | .000 |
| Total | 18 567 (100) | 10.3 | — | — | — | — |
GI, gastrointestinal.
a
Number and percentage of infants with the condition.
b
Prevalence in that subgroup.
c
OR (95% CI) and P report the OR, CI, and P value for the association of the condition and GERD. For polytomous categorical variables such as birth weight, the OR compares a level of the variable against a reference level.
d
Adjusted OR (95% CI) and P report the OR adjusted for all covariates in Tables 1 and 2.
e
Additional diagnostic variables (listed in the Methods) were examined in bivariate and multiple logistic analyses but were not included in this table because they were not significant in the multiple logistic regressions.