Table 2. Parameter estimates of the final pharmacokinetic model and bootstrap validation.

Parameter	Estimates of the model parameters			Bootstrap
	Estimates	SE%	Median	2.5th, 97.5th Percentiles
Pharmacokinetic parameter
CL (L·h−1·kg−1)	0.323	2.6	0.323	0.307, 0.339
V1 (L/kg)	0.086	4.2	0.0855	0.079, 0.094
Q (L·h−1·kg−1)	0.0957	3.0	0.0959	0.0908, 0.102
V2 (L/kg)	0.0554	3.3	0.0555	0.052, 0.059
Inter-individual variability
CL (%)	14.8	19.4	14.2	8.63, 20.0
V1 (%)	24.2	29.1	23.3	8.18, 36.2
Q (%)	−a	−a	−a	−a
V2 (%)	15.6	14.7	15.1	9.75, 19.4
Residual variability
Proportional error (%)	0.08	10.2	0.08	0.07, 0.09

^aInter-individual variability of Q could not be determined.