Table 3. Parameter estimates of the final pharmacokinetic-pharmacodynamic model and bootstrap validation.
| Parameter | Estimates of the model parameters |
|
Bootstrap |
|
|---|---|---|---|---|
| Estimates | SE% | Median | 2.5th, 97.5th Percentiles | |
| Pharmacodynamic parameter | ||||
| Emax (s) | 318 | 2.39 | 320 | 304, 340 |
| EC50 (mg/L) | 2.44 | 11.8 | 2.51 | 1.88, 2.99 |
| E0 (s) | 134 | 0.98 | 134 | 131, 136 |
| θRBC for EC50 | 1.70 | 3.54 | 1.69 | 0.23, 1.73 |
| Inter-individual variability | ||||
| Emax (%) | 6.80 | 28.5 | 6.33 | 0.50, 9.33 |
| EC50 (%) | 46.4 | 28.6 | 27.1 | 0.45, 62.6 |
| E0 (%) | 4.10 | 19.2 | 4.17 | 2.27, 5.58 |
| Residual variability | ||||
| Proportional error, % | 4.67 | 17.0 | 4.56 | 2.45, 6.06 |
θRBC was the coefficient of the RBC* on EC50.