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. 2014 Apr 1;9(6):1273–1283. doi: 10.1021/cb500062n

Figure 2.

Figure 2

RNAseq transcriptional profiling of stress-independent HSF1 activation. (A) Diagram showing the overlap of genes with >2-fold change (FDR < 0.01) in HEK293T-REx cells following dox-dependent cHSF1 overexpression or Shield-1-dependent FKBP·cHSF1 stabilization. (B) Plot showing the correlation between gene expression in HEK293T-REx cells following Shield-1-dependent FKBP·cHSF1 activation or dox-dependent cHSF1 overexpression. Only genes whose expression is significantly affected (FDR < 0.01) by dox-dependent cHSF1 overexpression are shown.