Figure 7.

A model showing how the distal half of compound 11 (magenta carbons, stick and surface representations) is proposed to exert a long-range inhibitory effect on the active site of BaDHPS via its interaction with the ordered loop1–loop7 substructure (orange-yellow) that is known to be required for catalysis.⁷ In this model, the structures of loop1 and loop2 (cyan) at the active site and the bound substrates DHP⁺ and pABA (shown as sticks) are based on the known structure of the YpDHPS intermediate-state catalytic complex.⁷