Table 6.

Effects of Markers of Inflammation, Endothelial Dysfunction, and Oxidative Stress on the Risk of Age-Related Macular Degeneration in Risk Assessment Models.

Marker^a	Traditional Risk Factor Model				Traditional Risk Factors + Genetic Factors Model

	AUC (95% CI)		Change in AUC, %	P value	AUC (95% CI)		Change in AUC, %	P value

	Without Markers in Model	With Marker in Model			Without Markers in Model	With Marker in Model
hsCRP	0.6714 (0.6212, 0.7216)	0.6786 (0.6295, 0.7277)	1.07	0.42	0.6923 (0.6411, 0.7435)	0.6997 (0.6492, 0.7502)	1.06	0.32
TNF-αR2		0.6715 (0.6217, 0.7214)	0.02	0.97		0.6926 (0.6417, 0.7435)	0.04	0.93
IL-6		0.6778 (0.6287, 0.7269)	0.95	0.47		0.6992 (0.6483, 0.7500)	0.98	0.38
WBC count		0.6747 (0.6239, 0.7255)	0.49	0.59		0.6962 (0.6445, 0.7479)	0.56	0.48
8-ISO		0.6726 (0.6221, 0.7232)	0.18	0.69		0.6927 (0.6412, 0.7443)	0.06	0.86
TCC		0.6750 (0.6251, 0.7249)	0.54	0.67		0.6953 (0.6443, 0.7462)	0.42	0.65
sVCAM-1		0.6720 (0.6215, 0.7226)	0.09	0.92		0.6956 (0.6437, 0.7474)	0.46	0.61
sICAM-1		0.6719 (0.6214, 0.7225)	0.08	0.82		0.6909 (0.6393, 0.7425)	-0.20	0.45

8-ISO, 8-isoprostane; AUC, area under the receiver operating characteristic curve; CI, confidence interval; hsCRP, high sensitivity C-reactive protein; IL-6, interleukin-6; TCC, total carbonyl content; TNF-αR2, tumor necrosis factor alpha receptor 2; sICAM-1, soluble intercellular adhesion molecule-1; sVCAM-1, soluble vascular cell adhesion molecule-1; WBC, white blood cell.

Traditional risk factors = age, sex, smoking status, physical activity, and body mass index.

Genetic factors = CFH rs1061770 and ARMS2 rs10490924.

Markers modeled per standard deviation on the logarithmic scale.