Table 6.
Markera | Traditional Risk Factor Model | Traditional Risk Factors + Genetic Factors Model | ||||||
---|---|---|---|---|---|---|---|---|
| ||||||||
AUC (95% CI) | Change in AUC, % | P value | AUC (95% CI) | Change in AUC, % | P value | |||
|
|
|||||||
Without Markers in Model | With Marker in Model | Without Markers in Model | With Marker in Model | |||||
hsCRP | 0.6714 (0.6212, 0.7216) | 0.6786 (0.6295, 0.7277) | 1.07 | 0.42 | 0.6923 (0.6411, 0.7435) | 0.6997 (0.6492, 0.7502) | 1.06 | 0.32 |
TNF-αR2 | 0.6715 (0.6217, 0.7214) | 0.02 | 0.97 | 0.6926 (0.6417, 0.7435) | 0.04 | 0.93 | ||
IL-6 | 0.6778 (0.6287, 0.7269) | 0.95 | 0.47 | 0.6992 (0.6483, 0.7500) | 0.98 | 0.38 | ||
WBC count | 0.6747 (0.6239, 0.7255) | 0.49 | 0.59 | 0.6962 (0.6445, 0.7479) | 0.56 | 0.48 | ||
8-ISO | 0.6726 (0.6221, 0.7232) | 0.18 | 0.69 | 0.6927 (0.6412, 0.7443) | 0.06 | 0.86 | ||
TCC | 0.6750 (0.6251, 0.7249) | 0.54 | 0.67 | 0.6953 (0.6443, 0.7462) | 0.42 | 0.65 | ||
sVCAM-1 | 0.6720 (0.6215, 0.7226) | 0.09 | 0.92 | 0.6956 (0.6437, 0.7474) | 0.46 | 0.61 | ||
sICAM-1 | 0.6719 (0.6214, 0.7225) | 0.08 | 0.82 | 0.6909 (0.6393, 0.7425) | -0.20 | 0.45 |
8-ISO, 8-isoprostane; AUC, area under the receiver operating characteristic curve; CI, confidence interval; hsCRP, high sensitivity C-reactive protein; IL-6, interleukin-6; TCC, total carbonyl content; TNF-αR2, tumor necrosis factor alpha receptor 2; sICAM-1, soluble intercellular adhesion molecule-1; sVCAM-1, soluble vascular cell adhesion molecule-1; WBC, white blood cell.
Traditional risk factors = age, sex, smoking status, physical activity, and body mass index.
Genetic factors = CFH rs1061770 and ARMS2 rs10490924.
Markers modeled per standard deviation on the logarithmic scale.