Figure 35.

Dynamics occurring in annexin A5 crystal captured by HS-AFM. (a) Binding and dissociation dynamics of annexin A5 trimer on the 2D crystal (scan area, 150 × 150 nm²; imaging rate, 2 fps). The hole in the honeycomb lattice indicated by the arrow in the image of t = 0 s was filled at 0.5 s by a trimer that had been diffusing on the crystal surface. In the next 0.5 s, the trimer was dissociated. Similar events occurred at several places in the crystal. (b) Model of the 2D crystal of annexin A5. The caged central trimer in the honeycomb structure is colored in pink.