Fig. 1.

The obese phenotype is maintained with EPA and DHA ethyl esters. A: Final mouse body weights after 5 and 10 weeks of feeding control, HF, HF-OA, HF-EPA, and HF-DHA diets. Fat mass (B), paraffin-embedded sections (C) of epididymal adipose tissue, and average adipocyte size (D) following 10 weeks of feeding. E: Relative gene expression of epididymal adipose tissue after 10 weeks of feeding. F: Glucose tolerance tests (GTTs) used to calculate the area under the curve (AUC) (G) and fasting insulin (H) were measured after 6 h of fasting for the 10 week feeding period. Data are average ± SE from six to twelve animals per diet, except (D), which are three animals per diet. Asterisks indicate significance from control unless indicated by a bracket: *P < 0.05, **P < 0.01, ***P < 0.001.