Fig. 1.

GW1516 attenuates diet-induced hepatic steatosis and body weight gain, without change in caloric intake. Ldlr^−/− mice were fed an HFHC diet for 4 weeks. For a subsequent 8 weeks, mice remained on HFHC alone or HFHC supplemented with GW501516 (GW1516) (3 mg/kg/day) (n = 12/group). A: Hepatic TG. B: Hepatic TC. C: Hepatic CE mass. D: Body weight. E: Caloric intake. Data are presented as mean ± SEM. Different letters indicate significant differences; one-way ANOVA with post hoc Tukey’s test (P < 0.05).