Fig. 5.

GW1516 corrects the gluconeogenic branch of insulin signaling during selective hepatic insulin resistance, which improves fasting hyperglycemia. A: Immunoblots of insulin signaling protein pFoxO1 in liver lysates from fasted (F) and refed (RF) mice (n = 6–8/group). Representative immunoblots with quantitations are shown. B: mRNA abundance of Pck1 in liver lysates isolated from F and RF animals (n = 6–8/group). C: Blood glucose levels in F and RF mice (n = 6–8/group). Data are presented as mean ± SEM. Different uppercase letters indicate statistical significance among fasted animals, different lowercase letters indicate statistical significance among refed animals, and asterisk (*) indicates statistical significance between fasted and refed within the same diet group (P < 0.05); two-way ANOVA with post hoc Tukey’s test (P < 0.05).