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. Author manuscript; available in PMC: 2015 Mar 10.
Published in final edited form as: Am J Med Genet C Semin Med Genet. 2014 Mar 10;0(1):56–67. doi: 10.1002/ajmg.c.31390

TABLE I.

Clinical Recommendations for Patients With Variant CYP2C19 Genotype

Phenotype Diplotype results Clinical recommendation regarding clopidogrel therapya
Extensive metabolizers *1/*1 Usual care
Intermediate metabolizers *1/(*2–*6, *8) (*2–*6, *8)/*17 Alternative therapy
Poor metabolizers *2/(*2–*6, *8)or any combination with two loss of functional alleles Alternative therapy
Ultrarapid metabolizers *1/*17, *17/*17 Usual care
Unknown Any combination containing *10 Usual care
a

Usual care was defined as clopidogrel 75 mg daily. Alternative therapy included either prasugrel 10 mg daily, ticagrelor 90 mg twice daily, or clopidogrel 225 mg daily (triple-dose clopidogrel was removed as an alternative option in March 2013).