TABLE I.
Phenotype | Diplotype results | Clinical recommendation regarding clopidogrel therapya |
---|---|---|
Extensive metabolizers | *1/*1 | Usual care |
Intermediate metabolizers | *1/(*2–*6, *8) (*2–*6, *8)/*17 | Alternative therapy |
Poor metabolizers | *2/(*2–*6, *8)or any combination with two loss of functional alleles | Alternative therapy |
Ultrarapid metabolizers | *1/*17, *17/*17 | Usual care |
Unknown | Any combination containing *10 | Usual care |
Usual care was defined as clopidogrel 75 mg daily. Alternative therapy included either prasugrel 10 mg daily, ticagrelor 90 mg twice daily, or clopidogrel 225 mg daily (triple-dose clopidogrel was removed as an alternative option in March 2013).