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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Handb Exp Pharmacol. 2014;221:137–168. doi: 10.1007/978-3-642-41588-3_7

Fig. 5.

Fig. 5

GS-458967 abolishes early afterdepolarizations (EADs) and EAD-induced triggered activity elicited by exposure to ATX-II in a canine Purkinje fiber. (a) ATX-II (10 nM) elicited EADs and EAD-induced triggered activity at basic cycle lengths (BCLs) of 2,000, 2,500, 3,500, 4,500, and 8,000 ms. GS-458967 (30 nM) abolished all EADs and triggered activity. From Sicouri et al. (2013) with permission