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. Author manuscript; available in PMC: 2014 Jun 30.
Published in final edited form as: J Bone Miner Res. 2013 Apr;28(4):865–874. doi: 10.1002/jbmr.1807

Table 1.

Effect of HLU and SclAb-II Treatment on Femoral Trabecular and Cortical Bone Microarchitecture, Assessed by μCT

Controls
 HLU
 ANOVA results
Site Vehicle SclAbll Vehicle SclAbll pload ptreatment pinteraction
Distal trabecular
    BV/TV (%) 10.3 ± 0.4b 32.0 ± 1.5a,b 8.0 ± 0.3 21.7 ± 1.2a <0.0001 <0.0001 <0.0001
    Tb.N (mm—1) 3.86 ± 0.04b 4.32 ± 0.05a,b 3.72 ± 0.05 4.05 ± 0.05a 0.0006 <0.0001 0.1
    Tb.Th (mm) 0.054 ± 0.001b 0.097 ± 0.002a,b 0.048 ± 0.001 0.075 ± 0.003a <0.0001 <0.0001 <0.0001
    Tb.Sp (mm) 0.252 ± 0.003b 0.198 ± 0.003a,b 0.261 ± 0.003 0.217 ± 0.005a 0.008 <0.0001 0.2
    ConnD (mm—3) 74 ± 3b 107 ± 3a 55 ± 5 108 ± 3a 0.3 <0.0001 0.06
    SMI 2.99 ± 0.06 1.4 ± 0.12a,b 3.05 ± 0.05 1.98 ± 0.08a 0.01 <0.0001 0.002
Distal cortical
    Tt.CSA (mm2) 2.49 ± 0.03 2.68 ± 0.05a,b 2.48 ± 0.05 2.54 ± 0.05 0.3 0.008 0.9
    Ct.BA (mm2) 0.71 ± 0.01b 0.96 ± 0.01a,b 0.57 ± 0.01 0.80 ± 0.02a <0.0001 <0.0001 0.7
    Ct.BA/TA (%) 28.5 ± 0.4b 35.5 ± 0.7a,b 22.8 ± 0.4 31.5 ± 0.2a <0.0001 <0.0001 0.06
    Ct.Por (%) 5.9 ± 0.2b 5.3 ± 0.2 7.9 ± 0.4 5.3 ± 0.4a 0.0006 <0.0001 0.003
    Ct.Th (mm) 0.12 ± 0.002b 0.15 ± 0.002a,b 0.10 ± 0.001 0.13 ± 0.001a <0.0001 <0.0001 0.08
    pMOl (mm4) 0.50 ± 0.01b 0.71 ± 0.02a,b 0.39 ± 0.01 0.57 ± 0.02a <0.0001 <0.0001 0.3
Midshaft cortical
    Tt.CSA (mm2) 1.56 ± 0.018 1.69 ± 0.024a,b 1.54 ± 0.030 1.58 ± 0.026 0.03 0.001 0.05
    Ct.BA (mm2) 0.66 ± 0.010b 0.86 ± 0.015a,b 0.55 ± 0.010 0.70 ± 0.012a <0.0001 <0.0001 0.02
    Ct.MA (mm2) 0.90 ± 0.014b 0.83 ± 0.013a 0.99 ± 0.023 0.88 ± 0.016a 0.0004 <0.0001 0.2
    Ct.BA/TA (%) 42.1 ± 0.5b 50.8 ± 0.4a,b 35.8 ± 0.5 44.2 ± 0.3a <0.0001 <0.0001 0.04
    Ct.Th (mm) 0.16 ± 0.002b 0.21 ± 0.003a,b 0.13 ± 0.002 0.17 ± 0.002a <0.0001 <0.0001 0.03
    TMD (mgHA/cm3) 1148 ± 5 1161 ± 8 1135 ± 4 1147 ± 7 0.09 0.1 0.7
    pMOI (mm4) 0.28 ± 0.01b 0.37 ± 0.01a,b 0.24 ± 0.01 0.29 ± 0.01a <0.0001 <0.0001 0.04

Values are mean ± SEM. BV/TV = bone volume fraction; CON = control; ConnD = connectivity density; Ct.BA = cortical bone area; Ct.BA/TA = cortical bone area fraction; Ct.MA = medullary area; Ct.Por = cortical porosity; Ct.Th = cortical thickness; HLU = hindlimb unloaded; pMOl = polar moment of inertia; SclAbll = sclerostin antibody; SMI = structure model index; Tb.N = trabecular number; Tb.Th = trabecular thickness; Tb.Sp = trabecular separation; TMD = tissue mineral density; Tt.CSA = total cross-sectional area; VEH = vehicle.

a

p < 0.05 SclAbll versus VEH within loading condition.

b

p < 0.05 CON versus HLU within treatment condition.