Case | Age | Gender | MLL2/3 Mutation* | PTCH/CTNNB1/TP53/PTEN Status | MYC Amplification* | OTX2 Amplification* | OTX2 Expression | Histopathologic Subtype | Survival |
---|---|---|---|---|---|---|---|---|---|
1 | 5 | Male | MLL2: missense (R4852Q) | no mutation | No | No | Positive | Severe Anaplastic | 5 years, alive |
2 | 11 | Male | MLL2: Frameshift | no mutation | ND | ND | Positive | Moderate Anaplastic | 6 years, alive |
3 | 7 | Female | MLL2: Nonsense (R4921X); MLL3: Nonsense (R2609X) | no mutation | Yes | No | ND | Large Cell | 3 months, deceased |