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. 2014 Jun 30;9(6):e100059. doi: 10.1371/journal.pone.0100059

Figure 1. Phylogenetic tree of cytochrome P450 genes in humans.

Figure 1

The tree includes all functional CYP genes in humans (Hosa) and all yeasts (Sace, Saccharomyces cerevisiae; Scpo, Schizosaccharomyces pombe). The tree was constructed using the NJ method for nucleotide differences between the CDS and rooted with yeast CYP51 gene sequences (Sace ERG11 and Scpo erg11). Red text indicates D-type CYP genes, and black and blue text indicate B-type CYP genes. The CYP1–4 families are indicated by a red bracket on the right side of the tree. Three diamonds (a, b, and c) indicate duplications of B- and D-type genes. The B-type genes that were the ancestors of D-type genes are indicated with a blue line and character. Black brackets and roman numerals (i–v) at the tips of the tree show five clusters of D-type genes: i, the CYP2 family on chromosome 19q; ii, the CYP2C subfamily on chromosome 10q; iii, the CYP3A subfamily on chromosome 7q; iv, the CYP4 family on chromosome 1p; v, the CYP4F subfamily on chromosome 19p. The number near each node indicates the bootstrap value (>94%) supporting the node.