Table 2. Clinical variables of the patients included in the clinical validation study.
| Low-risk PE | Intermediate or high-risk PE | P | |
| n = 52 | n = 52 | ||
| Clinical characteristics | |||
| Age, years | 70.6±16.8 | 67.1±16.8 | 0.128 |
| Male sex | 21 (40%) | 23 (44%) | 0.754 |
| BMI, kg/m2 | 27.8±6.7 | 25.9±4.1 | 0.252 |
| Risk factors for venous thromboembolism | |||
| Cancer* | 7 (13%) | 13 (25%) | 0.148 |
| Recent surgery† | 4 (7.7%) | 4 (7.7%) | 0.977 |
| Immobilization‡ | 11 (21%) | 5 (9.6%) | 0.094 |
| Comorbidities | |||
| Chronic obstructive pulmonary disease | 5 (9.6%) | 4 (7.7%) | 0.704 |
| Congestive heart failure | 1 (1.9%) | 2 (3.8%) | 0.569 |
| Echocardiography and cardiac biomarkers | |||
| RV dysfunction (echocardiogram) | 0 (0%) | 52 (100%) | <0.001 |
| BNP, pg/ml | 45±23 | 456±800 | <0.001 |
| cTnI, ng/ml | 0.001±0.01 | 0.15±0.26 | <0.001 |
Data are means ± SD or counts (percentage).
Abbreviations: BMI, body mass index; BNP, brain natriuretic peptide; cTnI, cardiac troponin I; PE, pulmonary embolism; RV, right ventricle.
*Active or under treatment in the last year.
†
In the previous month.
‡
Immobilized patients are defined in this analysis as non-surgical patients who had been immobilized (i.e., total bed rest with bathroom privileges) for ≥4 days in the month prior to PE diagnosis.