Table 3. Expression of metabolism-associated enzymes according to breast cancer phenotype.
| Parameters | Total (n = 709) (%) | Luminal A (n = 297) (%) | Luminal B (n = 168) (%) | HER-2 (n = 70) (%) | TNBC (n = 174) (%) | P-value |
| PHGDH in tumor | <0.001 | |||||
| Negative | 452 (63.8) | 253 (85.2) | 124 (73.8) | 33 (47.1) | 42 (24.1) | |
| Positive | 132 (75.9) | 44 (14.8) | 44 (26.2) | 37 (52.9) | 132 (75.9) | |
| PSAT1 in tumor | 0.061 | |||||
| Negative | 526 (74.2) | 229 (77.1) | 126 (75.0) | 43 (61.4) | 128 (73.6) | |
| Positive | 183 (25.8) | 68 (22.9) | 42 (25.0) | 27 (38.6) | 46 (26.4) | |
| PSPH in tumor | <0.001 | |||||
| Negative | 611 (86.2) | 284 (95.6) | 157 (93.5) | 55 (78.6) | 115 (66.1) | |
| Positive | 98 (13.8) | 13 (4.4) | 11 (6.5) | 15 (21.4) | 59 (33.9) | |
| PSPH in stroma | <0.001 | |||||
| Negative | 625 (88.2) | 287 (96.6) | 141 (83.9) | 54 (77.1) | 143 (82.2) | |
| Positive | 84 (11.8) | 10 (3.4) | 27 (16.1) | 16 (22.9) | 31 (17.8) | |
| SHMT1 in tumor | <0.001 | |||||
| Negative | 598 (84.3) | 284 (95.6) | 154 (91.7) | 59 (84.3) | 101 (58.0) | |
| Positive | 111 (15.7) | 13 (4.4) | 14 (8.3) | 11 (15.7) | 73 (42.0) | |
| SHMT1 in stroma | <0.001 | |||||
| Negative | 310 (43.7) | 156 (52.5) | 51 (30.4) | 19 (27.1) | 84 (48.3) | |
| Positive | 399 (56.3) | 141 (47.5) | 117 (69.6) | 51 (72.9) | 90 (51.7) | |
| GLDC in tumor | <0.001 | |||||
| Negative | 370 (52.2) | 138 (46.5) | 97 (57.7) | 26 (37.1) | 109 (62.6) | |
| Positive | 339 (47.8) | 159 (53.5) | 71 (42.3) | 44 (62.9) | 65 (37.4) | |
| GLDC in stroma | <0.001 | |||||
| Negative | 621 (87.6) | 271 (91.2) | 135 (80.4) | 53 (75.7) | 162 (93.1) | |
| Positive | 88 (12.4) | 26 (8.8) | 33 (19.6) | 17 (24.3) | 12 (6.9) |
TNBC, triple negative breast cancer.