Table 6. Correlations between expression of enzymes associated with serine/glycine metabolism and glycolysis.

Parameters	Glut-1 in tumor			CAIX in tumor			MCT4 in tumor
	Negative n  =  499 (%)	Positive n = 210 (%)	P-value*	Negative n = 499 (%)	Positive n = 210 (%)	P-value*	Negative n = 529 (%)	Positive n = 180 (%)	P-value*
PHGDH in tumor			<0.001			<0.001			0.132
Negative	361 (72.3)	91 (43.3)		349 (69.3)	106 (50.5)		350 (66.2)	102 (56.7)
Positive	138 (27.7)	119 (56.7)		153 (30.7)	104 (49.5)		179 (33.8)	78 (43.3)
PSAT1 in tumor			2.850			1.968			0.846
Negative	374 (74.9)	152 (72.4)		365 (73.1)	161 (76.7)		385 (72.8)	141 (78.3)
Positive	125 (25.1)	58 (27.6)		134 (26.9)	49 (23.3)		144 (27.2)	39 (21.7)
PSPH in tumor			<0.001			<0.001			<0.001
Negative	462 (92.6)	149 (71.0)		447 (89.6)	164 (78.1)		471 (89.0)	140 (77.8)
Positive	37 (7.4)	61 (29.0)		52 (10.4)	46 (21.9)		58 (11.0)	40 (22.2)
PSPH in stroma			0.120			2.784			0.240
Negative	449 (90.0)	176 (83.8)		437 (87.6)	188 (89.5)		474 (89.6)	151 (83.9)
Positive	50 (10.0)	34 (16.2)		62 (12.4)	22 (10.5)		55 (10.4)	29 (16.1)
SHMT1 in tumor			<0.001			0.018			0.216
Negative	456 (91.4)	142 (67.6)		434 (87.0)	164 (78.1)		455 (86.0)	143 (79.4)
Positive	43 (8.6)	68 (32.4)		65 (13.0)	46 (21.9)		74 (14.0)	37 (20.6)
SHMT1 in stroma			0.546			0.768			4.926
Negative	208 (41.7)	102 (48.6)		209 (41.9)	101 (48.1)		230 (43.5)	80 (44.4)
Positive	291 (58.3)	108 (51.4)		290 (58.1)	109 (51.9)		299 (56.5)	100 (55.6)
GLDC in tumor			1.332			<0.001			3.576
Negative	253 (50.7)	117 (55.7)		286 (57.3)	84 (40.0)		273 (51.6)	97 (53.9)
Positive	246 (49.3)	93 (44.3)		213 (42.3)	126 (60.0)		256 (48.4)	83 (46.1)
GLDC in stroma			0.144			4.746			2.922
Negative	428 (85.8)	193 (91.9)		436 (87.4)	185 (88.1)		466 (88.1)	155 (86.1)
Positive	71 (14.2)	17 (8.1)		63 (12.6)	25 (11.9)		63 (11.9)	25 (13.9)

*p-value was corrected by the Bonferroni method.