Table 7. Correlations between expression enzymes associated with serine/glycine metabolism and stromal expression of glycolysis-associated enzymes.

Parameters	Glut-1 in stroma			CAIX in stroma			MCT4 in stroma
	Negative n = 693 (%)	Positive n = 16 (%)	P-value*	Negative n = 595 (%)	Positive n = 114 (%)	P-value*	Negative n = 409 (%)	Positive n = 300 (%)	P-value*
PHGDH in tumor			1.482			0.618			<0.001
Negative	444 (64.1)	8 (50.0)		387 (65.0)	65 (57.0)		297 (72.6)	155 (51.7)
Positive	249 (35.9)	8 (50.0)		208 (35.0)	49 (43.0)		112 (27.4)	145 (48.3)
PSAT1 in tumor			6.000			0.462			4.710
Negative	514 (74.2)	12 (75.0)		449 (75.5)	77 (67.5)		305 (74.6)	221 (73.7)
Positive	179 (25.8)	4 (25.0)		146 (24.5)	37 (32.5)		104 (25.4)	79 (26.3)
PSPH in tumor			0.018			1.410			<0.001
Negative	602 (86.9)	9 (56.3)		517 (86.9)	94 (82.5)		372 (91.0)	239 (79.7)
Positive	91 (13.1)	7 (43.8)		78 (13.1)	20 (17.5)		37 (9.0)	61 (20.3)
PSPH in stroma			<0.001			<0.001			<0.001
Negative	619 (89.3)	6 (37.5)		542 (91.1)	83 (72.8)		392 (95.8)	233 (77.7)
Positive	74 (10.7)	10 (62.5)		53 (8.9)	31 (27.2)		17 (4.2)	67 (22.3)
SHMT1 in tumor			1.788			4.476			0.558
Negative	586 (84.6)	12 (75.0)		503 (84.5)	95 (83.3)		353 (86.3)	245 (81.7)
Positive	107 (15.4)	4 (25.0)		92 (15.5)	19 (16.7)		56 (13.7)	55 (18.3)
SHMT1 in stroma			0.060			<0.001			<0.001
Negative	308 (44.4)	2 (12.5)		292 (49.1)	18 (15.8)		236 (57.7)	74 (24.7)
Positive	385 (55.6)	14 (87.5)		303 (50.9)	96 (84.2)		173 (42.3)	226 (75.3)
GLDC in tumor			0.540			0.114			0.072
Negative	365 (52.7)	5 (31.3)		322 (54.1)	48 (42.1)		230 (56.2)	140 (46.7)
Positive	328 (47.3)	11 (68.8)		273 (45.9)	66 (57.9)		179 (43.8)	160 (53.3)
GLDC in stroma			<0.001			<0.001			<0.001
Negative	614 (88.6)	7 (43.8)		552 (92.8)	69 (60.5)		387 (94.6)	234 (78.0)
Positive	79 (11.4)	9 (56.3)		43 (7.2)	45 (39.5)		22 (5.4)	66 (22.0)

*p-value was corrected by the Bonferroni method.