Table 4. Association between IHC marker scores and individual DCIS lesions classified based on molecular subtypes of adjacent IDC and TDLU from patients with IDC and DCIS (n = 36).
| DCIS Classificationa | Ki-67 | p16 | p53 | ||||||
| Subgroups | Subtypes vs. IDC or TDLU | Lowb | Moderate (P)c | High (P) | Highb | Moderate (P) | Low (P) | Wild-typeb | Mutant (P) |
| I | Not same as IDCb | 79 | 42 | 4 | 18 | 54 | 51 | 119 | 7 |
| IIa | Same as IDC and TDLU | 50 | 46 (0.24) | 2 (0.69) | 15 | 25 (0.28) | 54 (0.84) | 99 | 0 (0.02) |
| IIb | Same as IDC but not as TDLU | 14 | 56 (2.1×10−8) | 23 (1.5×10−10) | 8 | 30 (0.64) | 53 (0.08) | 76 | 15 (0.02) |
a
DCIS lesions from each case were first classified into two subgroups based on the molecular subtypes of adjacent IDC: Subgroup I DCIS, which presented different molecular subtypes from the adjacent IDC; Subgroup II DCIS, which presented the same molecular subtypes as the adjacent IDC. Then the Subgroup II DCIS lesions were further divided into Subgroups IIa and IIb based on the molecular subtypes of adjacent TDLU.
b
Reference category.
c
P-value (Fisher's exact test).