Table 3. Summary of ORs of the -260C/T polymorphism and gastric cancer risk by H. pylori infection status and location.
Variables | na | dominant model | recessive model | CT vs. CC | TT vs. CC | ||||||||
OR(95% CI) | P b | I 2 | OR(95% CI) | P b | I 2 | OR(95% CI) | P b | I 2 | OR(95% CI) | P b | I 2 | ||
H. pylori infection | |||||||||||||
H. pylori (+) | 3/2* | 1.51(0.58,3.92) | 0.01 | 76 | 1.28(0.95,1.73) | 0.59 | 0 | 2.04(1.21,3.46) | 0.38 | 0 | 2.32(1.36,3.94) | 0.32 | 0 |
H. pylori (−) | 3/2* | 1.44(0.75,2.77) | 0.51 | 0 | 1.26(0.83,1.93) | 0.16 | 49 | 1.52[0. 73,3.14] | 0.77 | 0 | 1.90(0.89,4.08) | 0.46 | 0 |
Location | |||||||||||||
Cardia | 3 | 0.75(0.54,1.04) | 0.67 | 0 | 0.84(0.58,1.22) | 0.33 | 11 | 0.77(0.54,1.10) | 0.42 | 0 | 0.69(0.44,1.06) | 0.68 | 0 |
Non-cardia | 3 | 0.83(0.63,1.08) | 0.33 | 9 | 0.90(0.68,1.19) | 0.25 | 28 | 0.83(0.62,1.11) | 0.56 | 0 | 0.80(0.57,1.13) | 0.15 | 48 |
Number of comparison,
Test for heterogeneity,
* 3 studies in the dominant model, 2 in the other models.