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. 2014 Jun 30;9(6):e100285. doi: 10.1371/journal.pone.0100285

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© 2014 Yang et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Healthy control group. (B) Untreated periodontitis group. (C) iPSC-MSCs treated periodontitis group. (D) iPSC-MSCs/TSG-6 treated periodontitis group. TRAP-positive osteoclasts in rat maxillae showed a significant decrease in iPSC-MSCs/TSG-6 treated group. (AB = alveolar bone, PDL = periodontal ligament, R = tooth root, black arrow = TRAP-positive osteoclasts) (TRAP staining, scale bar, 50 µm). (E) Quantitative analysis of TRAP-positive osteoclasts (nuclei≥3) showed a significantly decreased number of osteoclasts in iPSC-MSCs and iPSC-MSCs/TSG-6 treated group, compared to untreated periodontitis group; the decrease number of osteoclasts showed a significant differences between iPSC-MSCs/TSG-6 and iPSC-MSCs treated group.