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. Author manuscript; available in PMC: 2015 Mar 12.
Published in final edited form as: Adv Mater. 2013 Dec 12;26(10):1494–1533. doi: 10.1002/adma.201304431

Figure 18. Integrated microenvironment for studying cancer metastasis in vitro.

Figure 18

(a) Schematic of tumor cell-microenvionment interactions during the progression and metastasis of cancer. See text for detailed descriptions. (b) (upper left) Schematic of a representative gel-in-microfluidics assay for studying tumor cell intravasation. (upper right) Phase contrast image of the reconstituted tumor cell-endothelium interface. (bottom) Time-lapse confocal images showing a tumor cell invading and penetrating TNF-α stimulated endothelial monolayer.[344] Reproduced with permission from [344]. Copyright 2012, United States National Academy of Sciences.