Figure 3. CJ2-gD2 exhibits superior vaccine efficacy than gD2-alum/MPL subunit vaccine in protecting against intravaginal wild-type HSV-2 infection in guinea pigs.
Female guinea pigs sham-immunized with DMEM or immunized with gD2-alum/MPL or CJ2-gD2 described in Fig. 2 were challenged intravaginally with 5×105 PFU of HSV-2 strain MS. Vaginal swabs were taken on days 1, 2, 3, 5, 7, and 9 post-challenge. Infectious virus on swab materials was determined by standard plaque assay in Vero cells. Viral yields are expressed as the means ± SEM for individual swabs (A). The duration of viral shedding is represented as the mean number of days during which infectious virus was detected in vaginal swabs ± SEM (B).