Table 1. SNPs validated in the phase II.

					NXC-GWAS				NXC-VAL
CHR	Gene†	SNPs	BP‡	A1	MAF A	MAF U	P	OR	MAF A	MAF U	P	OR
4q26	NDST3	rs3987*	118978503	C	0.470	0.393	0.000125	1.37	0.513	0.435	8.14E-05	1.36
4q26	NDST3	rs1023890*	118920894	A	0.497	0.419	0.000127	1.37	0.541	0.465	0.000114	1.35
4q26	NDST3	rs1870481	118882468	T	0.495	0.421	2.40E-04	1.35	0.538	0.462	0.000135	1.35
4q26	NDST3	rs2169059	118926638	A	0.495	0.423	3.90E-04	1.33	0.541	0.466	0.000141	1.35
4q26	NDST3	rs1459528	118969796	G	0.492	0.417	1.96E-04	1.35	0.529	0.462	0.00062	1.30
4q32.1	FAM198B	rs2881373	159312083	T	0.197	0.141	1.71E-04	1.50	0.199	0.160	0.00759	1.30
5p15.1	MYO10	rs588367	16709570	A	0.305	0.388	2.85E-05	0.69	0.331	0.369	0.04218	0.84
5p15.1	MYO10	rs428263	16711495	T	0.310	0.387	7.66E-05	0.71	0.330	0.369	0.04125	0.84
5p15.1	MYO10	rs876095	16709803	T	0.310	0.387	8.81E-05	0.71	0.331	0.369	0.04218	0.84
12q23.1	AK307646	rs3858655*	95404373	T	0.167	0.126	3.46E-03	1.39	0.176	0.141	0.01329	1.29
12q23.1	AK307646	rs17375557*	95442660	A	0.174	0.131	3.34E-03	1.39	0.178	0.144	0.016	1.28
11q24.1	SORL1	rs11218350*	120957861	T	0.254	0.204	3.22E-03	1.32	0.253	0.214	0.01767	1.24
4q32.1	TMEM144	rs7664129*	159189132	C	0.148	0.106	1.47E-03	1.47	0.151	0.122	0.03151	1.27
13q14.11	ENOX1	rs4941455*	42799471	A	0.151	0.193	7.34E-03	0.74	0.156	0.186	0.04799	0.81
9p13.2	PAX5	rs11999298*	36884151	T	0.070	0.051	4.71E-02	1.4	0.070	0.052	0.04759	1.36

CHR: Chromosome; SNP: Single Nucleotide Polymorphism; BP: Base pair position; A1: Reference allele (minor allele). The last eight columns show the minor allele frequency in cases (MAF A), the minor allele frecuency in controls (MAF U) and, the p and the Odds Ratio (OR) values obtained in each analyzed sample.

*SNPs selected by two-locus association analyses in the NXC-GWAS sample.

^†The nearest gene or the gene where the SNP is located.

^‡According to UCSC genome browser (NCBI36/hg18) and dbSNP build 130.