Table 2. Meta-analysis of SNPs validated in the phase II.
CHR | Gene† | SNPs | BP‡ | A1 | P | P(R) | OR | OR(R) | Q | I |
4q26 | NDST3 | rs3987* | 118978503 | C | 4.02E-08 | 4.02E-08 | 1.36 | 1.36 | 0.94 | 0 |
4q26 | NDST3 | rs1023890* | 118920894 | A | 5.61E-08 | 5.61E-08 | 1.36 | 1.36 | 0.90 | 0 |
4q26 | NDST3 | rs1870481 | 118882468 | T | 1.23E-07 | 1.23E-07 | 1.35 | 1.35 | 0.99 | 0 |
4q26 | NDST3 | rs2169059 | 118926638 | A | 2.04E-07 | 2.04E-07 | 1.34 | 1.34 | 0.93 | 0 |
4q26 | NDST3 | rs1459528 | 118969796 | G | 4.57E-07 | 4.57E-07 | 1.33 | 1.33 | 0.74 | 0 |
4q32.1 | FAM198B | rs2881373 | 159312083 | T | 6.86E-06 | 6.86E-06 | 1.39 | 1.39 | 0.35 | 0 |
5p15.1 | MYO10 | rs588367 | 16709570 | A | 0.000013 | 0.007262 | 0.76 | 0.76 | 0.10 | 62.7 |
5p15.1 | MYO10 | rs428263 | 16711495 | T | 0.000026 | 0.003224 | 0.77 | 0.77 | 0.15 | 51.5 |
5p15.1 | MYO10 | rs876095 | 16709803 | T | 0.00003 | 0.00312 | 0.77 | 0.77 | 0.15 | 50.5 |
12q23.1 | AK307646 | rs3858655* | 95404373 | T | 0.000147 | 0.000147 | 1.34 | 1.34 | 0.63 | 0 |
12q23.1 | AK307646 | rs17375557* | 95442660 | A | 0.000175 | 0.000175 | 1.33 | 1.33 | 0.60 | 0 |
11q24.1 | SORL1 | rs11218350* | 120957861 | T | 0.000179 | 0.000179 | 1.28 | 1.28 | 0.61 | 0 |
4q32.1 | TMEM144 | rs7664129* | 159189132 | C | 0.000197 | 0.000197 | 1.35 | 1.35 | 0.38 | 0 |
13q14.11 | ENOX1 | rs4941455* | 42799471 | A | 0.001042 | 0.001042 | 0.77 | 0.77 | 0.57 | 0 |
9p13.2 | PAX5 | rs11999298* | 36884151 | T | 0.005207 | 0.005207 | 1.38 | 1.38 | 0.92 | 0 |
CHR: Chromosome; SNP: Single Nucleotide Polymorphism; BP: Base pair position; A1: Reference allele (minor allele); P: Fixed-effects p-value; P(R): Random-effects p-value; OR: Fixed-effects Odds Ratio; OR(R): Random-effects Odds Ratio; Q: p-value for heterogeneity of OR; I: effect size for heterogeneity of OR.
*SNPs selected by two-locus association analyses in the NXC-GWAS sample.
The nearest gene or the gene where the SNP is located.
According to UCSC genome browser (NCBI36/hg18) and dbSNP build 130.