Table 3. Best SNP×SNP interactions validated in the phase II and meta-analysis results.

			NXC- GWAS		NXC-Val		Pooled analysis
CHR	Gene†	SNP pair	OR	p	OR	p	OR	p
6.22p/10.q22.3	ATXN1/ANXA11	rs9464886 AG rs2784773 AA	2.70	1.07E-07	1.52	0.009628	1.88103	9.27E-08
2q35/4q26	MREG/NDST3	rs3770542 AA rs1023890 GG	2.28	7.63E-07	1.59	0.000762	1.73924	1.00E-07
7q31.33/19q12	GPR37/LOC100420587	rs1100508 CG rs8111948 AA	3.16	1.40E-09	1.73	0.001048	2.22646	4.35E-11
12p11.22/21q22.12	FAR2/DOPEY2	rs4931122 AA rs7280997 TT	2.85	3.40E-09	1.59	0.007512	2.16412	1.28E-10
12q14.1/12q23.1	FAM19A2/AK307646	rs2731402 CC rs17375557 AG	2.20	1.34E-06	1.50	0.005473	1.73009	2.49E-07

SNP: Single Nucleotide Polymorphism; OR: HFCC Odds Ratio; P: value associated with HFCC OR (1 df).

^†The nearest gene or the gene where the SNP is located.