FIG. 2.

Effect of estrogen on growth of the female reproductive tract in ovariectomized guinea pigs. A) Vulva of ovariectomized guinea pigs treated with vehicle was characterized by a membrane covering the vaginal introitus (arrow). The membrane was dissolved in estrogen-treated animals. B) Vaginal (vag, light gray bar), uterine (ut, dark gray bar), and cervical (cvx, black bar) weight were increased significantly in estrogen-treated animals compared with vehicle-treated controls. Bladder (Bl, white bar) weights were similar between the two groups. Each bar represents mean ± SEM from six animals in each group. *P < 0.01 compared with corresponding organ from controls. C) Gross appearance of female reproductive tract in vehicle and estrogen-treated animals.