FIG. 1.

A subset of progesterone transcriptional responses in the murine endometrium requires SRC-2. A) Schematic of the experimental design for the microarray study. Six-week-old SRC-2^f/f (control) and SRC-2^d/d (SRC-2-depleted) mice were ovariectomized and rested for 2 wk. Two weeks postsurgery, mice were treated with either sesame oil (vehicle control) or P4 for 6 h before uterine RNA was processed for microarray analysis. B) Colorgram of differential gene expression in uteri from vehicle control or P4-treated ovariectomized SRC-2^f/f and SRC-2^d/d mice. The extent of gene expression changes is represented by a blue-yellow color scale (blue: high expression; yellow: low expression; black: no change). C) Table shows the number of unique endometrial genes that are acutely induced or repressed by P4 (SRC-2^f/f P4 treatment vs. SRC-2^f/f Oil treatment) and the number of unique endometrial genes that are induced or repressed by P4, which are dependent on SRC-2 expression (SRC-2^d/d P4 treated vs. SRC-2^f/f P4 treated).