Skip to main content
. 2014 Feb 5;90(3):62. doi: 10.1095/biolreprod.113.111393

FIG. 1.

FIG. 1

Testis morphogenesis in control and Smad4 conditional knockout mouse embryos at E15.5 and E19.5. A–F) Developmental time course of testes from control (A, D), Leydig Smad4 cKO (B, E), and Sertoli/Leydig Smad4 cKO (C, F) embryos. Bars = 100 μm. White arrows indicate underdeveloped testis cords. G–I) Whole mount images of testes in representative E19.5 control (G), Leydig Smad4 cKO (H), and Sertoli/Leydig Smad4 cKO mice (I). The epididymis was removed to allow for easier visualization of testicular hemorrhages in the Sertoli/Leydig Smad4 cKO testis (I). Yellow arrowhead indicates hemorrhagic regions. E, epididymis.