FIG. 1.

βERKO mice spend more time in E and MET but less time in DI compared to WT mice. Cyclicity in WT and βERKO mice as determined by daily vaginal smears. A) Vaginal smears were taken for 45–50 consecutive days and scored to be either PRO, E, MET, or DI. Representative profiles of one WT and one βERKO animal are shown. B) Percentage of time spent in each stage of the cycle (mean ± SEM). Significant P-values between WT and βERKO mice in each stage are shown. Genotypes were compared using two-sample t-tests; P-values are two sided. PRO, proestrus; MET, metestrus; DI, diestrus; E, estrus.