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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Psychoneuroendocrinology. 2014 Apr 6;45:142–153. doi: 10.1016/j.psyneuen.2014.03.018

Figure 3.

Figure 3

NTS GR signaling inhibits corticosterone response to acute restraint. (A) NTS CHOL, CORT or mifepristone micropellets does not alter baseline AM corticosterone levels. (B) At 60 min after initiation of restraint, mifepristone micropellet-implanted rats have increased plasma corticosterone levels, whereas CORT micropellet-implanted rats exhibited decreased corticosterone levels. (C) NTS mifepristone micropellets increased integrated corticosterone response to acute stress. (D-F) Animals with CHOL, CORT or mifepristone micropellet-implanted to adjacent off target areas showed no difference in their baseline AM plasma corticosterone levels, post-restraint time course corticosterone levels, or total corticosterone response to acute restraint. Data are presented as mean ± SEM. For NTS hits: n=8 (CORT implanted), n= 8 (mifepristone implanted), n=10 (CHOL implanted animals). For NTS misses: n= 4 (CORT implanted) n=5 (mifepristone implanted). *p <0.05 vs. CHOL and CORT. #p <0.05 vs. CHOL and mifepristone. *#p <0.05 vs CHOL and CORT. AUC= area under curve.

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