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. 2014 Jun 20;47(2):117–126. doi: 10.5115/acb.2014.47.2.117

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Copyright © 2014. Anatomy & Cell Biology

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 5 — CA1 area of hippocampus. (A) Adult balanced diet fed rats shows, typical pyramidal cells (dashed lines) with triangular bodies, basophilic rim of cytoplasm, large vesicular nuclei (N) and prominent nucleoli. The oligodendroglia cell (arrowhead) lies adjacent to the pyramidal cell membrane. (B, C) Aged balanced diet fed rats shows, a senile neuritic plaque (dashed circle), apoptotic oligodendroglia (arrowheads) and the pyramidal cells either sclerotic (thin arrow) or dark shrunken (thick arrow). (D) Adult cholesterol diet fed rats shows, eosinophilic degenerated pyramidal cell with disintegrated axon (thick arrow), other pyramidal cells become swelling (thin arrow). Also, there are eosinophilic Hirano body (curved arrow) and Lipofuscin pigmentation (corrugated arrow). (E) Aged cholesterol diet fed rats shows, extra neural Hirano bodies (arrows), both intracellular tangles (triangle arrowhead) and granulovacuolar degeneration (tailed arrowhead), Lewy's body (crossed arrow) and apoptotic oligodendroglia (hollow arrowhead) (A-E, H&E, ×1,000).