Table 1.
The effect of WAY100635, prazosin or clonidine on the striatal dopamine, DOPAC and HVA
| Dopamine | DOPAC | HVA | Turnover rate | |
|---|---|---|---|---|
| Vehicle |
19.49 ± 0.75** |
1.62 ± 0.12** |
1.03 ± 0.04** |
0.14 ± 0.01 |
| WAY100635 (0.05 mg/kg) |
18.22 ± 1.21** |
1.73 ± 0.09** |
0.91 ± 0.04** |
0.15 ± 0.01 |
| prazosin (0.03 mg/kg) |
20.27 ± 2.33** |
1.51 ± 0.14** |
0.79 ± 0.09** |
0.12 ± 0.01
#
|
| clonidine (0.15 mg/kg) |
22.76 ± 1.88** |
1.47 ± 0.07** |
0.84 ± 0.05** |
0.10 ± 0.01
##
|
| MPTP |
3.38 ± 0.35 |
0.51 ± 0.05 |
0.44 ± 0.04 |
0.28 ± 0.01
##
|
| MPTP + mirtazapine (16 mg/kg) |
1.90 ± 1.21 |
0.38 ± 0.08 |
0.29 ± 0.06 |
0.78 ± 0.25* |
| MPTP + mirtazapine (16 mg/kg) + WAY100635 (0.05 mg/kg) |
2.25 ± 0.47 |
0.40 ± 0.10 |
0.32 ± 0.08 |
0.33 ± 0.05† |
| MPTP + mirtazapine (16 mg/kg) + prazosin (0.03 mg/kg) |
3.49 ± 0.48 |
0.56 ± 0.04 |
0.37 ± 0.01 |
0.28 ± 0.03† |
| MPTP + mirtazapine (16 mg/kg) + clonidine (0.15 mg/kg) | 2.90 ± 0.68 | 0.58 ± 0.68 | 0.45 ± 0.07 | 0.31 ± 0.04† |
The results are shown as the mean (μg/g tissue) ± SEM of 4–6 animals/group. Statistical significance was evaluated by Student-Newman-Keuls test (F(DA) 8,40 = 84.267, F(DOPAC) 8,40 = 32.896, F(HVA) 8,40 = 29.578, F(Turnover) 8,40 = 4.232, *P < 0.05,**P < 0.01 compared with MPTP-treated group and †P < 0.05 compared with MPTP + mirtazapine group), or by Student’s t-test ( # P < 0.05, ## P < 0.01 compared with vehicle group).