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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Dev Cell. 2013 Jun 6;25(6):610–622. doi: 10.1016/j.devcel.2013.05.004

Figure 7. Summary of Oct4 null phenotype and working model.

Figure 7

A) In normal embryos, Oct4 promotes survival of all three blastocyst lineages, facilitating transcription of components of multiple metabolic pathways, as well as lineage-specific, cell fate-determining transcription factors. B) In EPI cells, Oct4 induces expression of multiple genes, including signaling molecules such as Fgf4 that induce PE cell fate non cell-autonomously. In PE cells, Oct4 normally acts downstream of Mapk to promote expression of Sox17, Pdgfra, Gata4, Sox7, and eventually Gata6. In parallel, Mapk represses Nanog in an Oct4-independent manner in PE cells. Also in parallel, Oct4 represses expression of Cdx2 and other TE genes in all ICM cells.