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. 2014 Jul;184(7):2035–2044. doi: 10.1016/j.ajpath.2014.03.005

Figure 5.

Figure 5

Effects of alcohol and betaine on mitochondrial cholesterol, liver GSH, mitochondrial integrity, and the extent of apoptosis. Six rats per group were pair fed their respective HFC, HFE, and HFEB liquid diets for 8 weeks, after which they were sacrificed to obtain liver samples for measuring mitochondrial cholesterol (A), mitochondrial GSH (B), cytochrome c (C), caspase 3 activity (D), and CS activity (E), as described in Materials and Methods. Data are expressed as means ± SD in each group. Statistical significance of variance was calculated using Tukey's test: ∗P < 0.05, ∗∗P < 0.01 versus HFC; †P < 0.05, ††P < 0.01 versus HFE.