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. 2014 Jul;184(7):2035–2044. doi: 10.1016/j.ajpath.2014.03.005

Figure 6.

Figure 6

Effects of alcohol and betaine on PGC-1 signaling pathway genes and corresponding proteins involved in lipogenesis and lipid oxidation. Six rats per group were pair fed their respective HFC, HFE, and HFEB liquid diets for 8 weeks, after which they were sacrificed and the hepatic mRNA expressions were determined by quantitative real-time PCR, as described in Materials and Methods for PGC-1β (A), SREBP1c (B), ACC (C), SREBP2 (D), HMG-CoA reductase (E), PGC-1α (F), CPT-1 (G), and SIRT1 (H). The results are expressed as means ± SD in each group. Statistical significance of variance was calculated using Tukey's test: ∗P < 0.05, ∗∗P < 0.01 versus HFC; †P < 0.05, ††P < 0.01 versus HFE.