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. 2014 Jul;184(7):2035–2044. doi: 10.1016/j.ajpath.2014.03.005

Figure 7.

Figure 7

Effects of alcohol and betaine on PGC-1β signaling pathway proteins involved in lipogenesis. Six rats per group were pair fed their respective HFC, HFE, and HFEB liquid diets for 8 weeks, after which they were sacrificed and hepatic protein expressions were determined by using Western blot analysis, as described in Materials and Methods for PGC-1β (A), SREBP-1c (B), SREBP2 (C), HMG-CoA reductase (D), ACC (E), pACC (F), AMPK (G), and pAMPK (H). The results are expressed as means ± SD in each group. Statistical significance of variance was calculated using Tukey's test: ∗∗P < 0.01, ∗∗∗P < 0.001 versus HFC; †P < 0.05, ††P < 0.01, and †††P < 0.001 versus HFE.