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Activation of downstream signaling pathways in Schwann cell tumors. IHC for downstream effectors of EGFR (pEGFR, pErk, and pAkt) and Trp53 (p21) signaling. A: IHC images for either neurofibromas (n = 6) or grade 3 PNSTs (n = 13) from Cnp-EGFR;Trp53+/− mice. B: Scoring for IHC: 0, negative; 1, <25% of tumor; 2, 25% to 75% of tumor; and 3, >75% of tumor staining positive. Statistics were performed with an unpaired Student's t-test: ∗∗∗∗P < 0.0001. Original magnification, ×400 (A).
