Table 3.
Signaling Pathway Analysis of aCGH Focal Gain Regions
| Signaling pathway | B-H corrected P value | Genes |
|---|---|---|
| ERK5 | 0.0005 | SH2D2A, MYC, RPS6KA6, MEF2D, NTRK1, RPS6KA3, CREB3L4 |
| Ephrin receptor | 0.0046 | PTK2, SHC1, GNB4, GNB3, GNB2, EFNA3, CREB3L4, EFNA4, EFNA1 |
| Phospholipase C | 0.0063 | SHC1, GNB4, PRKC1, GNB3, MEF2D, GNB2, RPS6KA3, LYN ARHGEF2, CREB3L4 |
| Axonal guidance | 0.0120 | ADAM14, EFNA3, SEMA6C, EFNA4, EFNA1, PTK2, SHC1, GNB4, PRKC1, GBN3, NTRK1, GNB2, SEMA4A |
| Tec kinase | 0.0324 | PTK2, GNB4, PRKC1, GNB3, HCK, GNB2, LYN |
| Ephrin A | 0.0380 | PTK2, EFNA3, EFNA4, EFNA1 |
| Polyamine regulation | 0.0380 | MCY, ODC1, OAZ3 |
| P2Y purinergic receptor | 0.0380 | MYC, GNB4, PRKC1, GNB3, GNB2, CREB3L4 |
B-H, Benjamini-Hochberg.