Skip to main content
. 2014 Jul;184(7):2134–2143. doi: 10.1016/j.ajpath.2014.04.001

Figure 1.

Figure 1

IL-19 regulates neointimal hyperplasia. A:IL-19−/− mice demonstrate exacerbated response to ligation injury compared with WT age- and sex-matched littermates. Quantitative morphological analysis determines a significantly increased N/I ratio in IL-19−/− (n = 13) compared with WT (n = 9) mice. B: Injection of recombinant IL-19 into IL-19−/− mice can rescue the IL-19−/− response to injury phenotype. Quantitative morphological analysis determined significantly decreased N/I ratio in mice injected with 10 ng/g per day rIL-19 i.p. (n = 11) or PBS (n = 10) 5 days per week for 28 days. C: IL-19 reduces intimal hyperplasia in FVB WT mice. Injection of recombinant IL-19 significantly decreased the N/I ratio in mice injected with 10 ng/g per day rIL-19 i.p. (n = 11) or PBS (n = 10) 5 days per week for 28 days (P < 0.01). Representative photomicrographs are stained with H&E. ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001. Original magnification, ×200.