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. 2014 Jul;144(1):105–114. doi: 10.1085/jgp.201311140

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© 2014 Mruk et al.

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Figure 3. — Multiple Na_V1.5 CaM-binding regions are predicted by the meta-analysis. Meta-analysis of the Na_V1.5 (A) IQ domain and (C) DIII–IV linker. Yellow highlighted residues denote the meta-analysis CaM-binding domain predictions. Hatched box and red underlined residues denote target peptide and anchor residues shown in B and D; NA in the hatched box represents the peptide sequence (NAQKKYYNAMK) that was determined in D. Motif score equals the number of times an amino acid is found in a unique canonical CaM-binding motif. Ribbon diagrams of CaM bound to the Na_V1.5 (B) IQ domain (Protein Data Base accession no. 4DCK) and (D) DIII–IV linker (PDB accession no. 4DJC). Predicted residues (yellow) are shown on a blue target peptide. Red space fill, anchor residues; cyan with gray calcium ions, CaM.