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Cell specificity of linear ubiquitin dependent activation of IKK complex and inflammasome in mice. In mouse embryonic fibroblasts (A), expression of IL-6 and pro–IL-1β upon LPS is dependent of LUBAC activity. In BMDM (B), expression of IL-6 and pro–IL-1β upon LPS is independent of LUBAC activity but IL-1β secretion is dependent of linear ubiquitination of ASC.
