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. 2014 Jun 30;211(7):1281–1288. doi: 10.1084/jem.20132336

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© 2014 Patnode et al.

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Figure 4. — Involvement of LTB₄ in collective eosinophil migration. (A) Migration of eosinophils across Transwell membranes in response to CCL11 or leukotrienes. (B) LTB₄ and LTE₄ production in wild-type or Alox5^−/− eosinophils treated with 1 µM ionomycin. Where indicated, cells were treated with 10 µM MK886. (C) LTB₄ and LTE₄ production in wild-type eosinophils incubated with C. elegans dauers. Where indicated, cells were treated with 10 µM MK886. (D) Accumulation of wild-type and Ltb4r1^−/− eosinophils in response to C. elegans dauers (n ≥ 12 per experiment). (E) Eosinophil (Eos) and neutrophil (Neut) accumulation around C. elegans dauers (n ≥ 18). (F) Accumulation of wild-type and Alox5^−/− neutrophils around IgG₁- or F(ab′)₂-coated agarose beads (n ≥ 8). (A–F) Results represent two (A–C, E, and F) or are pooled from four (D) independent experiments. Error bars indicate standard error of the mean. *, P < 0.05; **, P < 0.005; ***, P < 0.0005.