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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Pulm Pharmacol Ther. 2012 Jul 16;26(1):75–85. doi: 10.1016/j.pupt.2012.07.002

Fig. 3. Epigenetic regulation of genes associated with remodeling.

Fig. 3

Histone lysine methylation regulates differential VEGF expression from ASM cells isolated from non-asthmatic donors compared to non-asthmatic donors. Histone acetylation is involved in the transcriptional regulation of Endothelin-1 (ET-1) and MMPs but its involvement in dysregulation of these genes expression in disease has yet to be investigated. Increased CpG methylation of the 5′ flanking region of the extracellular superoxide dismutase (EC-SOD) gene represses EC-SOD expression and may be implicated in pulmonary arterial hypertension pathogenesis.