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. 2014 May 28;16(3):R53. doi: 10.1186/bcr3664

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Copyright © 2014 Aguilar et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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A chemical compound screen identifies an activator of soluble guanylyl cyclase as reducing the viability of long-term estrogen-deprived MCF7 cells. (A) Compounds with no differential effect (top panel), with an inhibitory effect on the long-term estrogen deprivation (LTED) of MCF7 cells (MCF7-LTED cells) relative to MCF7 cells (middle panel) and with an inhibitory effect on MCF7 relative to MCF7-LTED cells (bottom panel). The y-axis indicates relative viability of MCF7-LTED cells, and the x-axis indicates increasing concentrations of the compounds. Colored lines indicate average values. (B) Corroboration of the inhibitory effect of YC-1 on MCF7-LTED cells. (C) Time-dependent increase of cGMP in MCF-LTED cells exposed to YC-1.