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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: J Tissue Eng Regen Med. 2012 Jul 5;8(1):15–28. doi: 10.1002/term.1487

Figure 9.

Figure 9

Schematic diagram showing the presentation of NP grafted BMP2 peptides/proteins to cell surface receptors: (a) an NP (gray) grafted with many BMP2 peptides/proteins (blue) provides a high concentration of the peptide/protein locally on the cell surface for interaction with a cluster of BRI (orange/yellow) and BRII (violet/yellow) receptors; many BMP2 peptides/proteins on the NP interact locally with BRI and BRII receptors (b) to form BRI/BRII complexes (c); the formation of multiple localized BRI/BRII complexes leads to an intense activation of downstream osteogenic pathways (shown by red arrow).